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Parkinsonism Induced by Solvent Abuse
Ann NEurol 35:616-618, Uitti,R.J.,et al, 1994
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Article Abstract
We report the first description of a patient with parkinsonism induced by solvent abuse.Our patient developed parkinsonism acutely,following heavy abuse of lacquer thinner.Her clinical deficits were indistinguishable from idiopathic parkinsonism(Parkinson's disease)and she responded to levodopa. Parkinsonism has persisted for more than 3 months.Brain computed tomography was normal.Positron emission tomographic studies showed normal floradopa uptake and reduced raclopride binding,indicating an unusual disturbance of striatal dopaminergic function.This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.
 
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drug induced neurologic disorders
huffing
L-dopa
movement disorder,drug induced
neurotoxin
Parkinson disease
Parkinson disease,drug induced
solvent
toxins,nervous system

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